phospholipase c meaning in English
磷脂酶c
Examples
- This response was mediated by gi and subsequent activation of phospholipase c ( plc ) , which triggered two pathways : protein kinase c ( pkc ) led to repulsion , and inositol 1 , 4 , 5 - triphosphate ( ip3 ) receptor activation led to attractive turning
信号转导机制的研究表明， sdf - 1和baclofen激活了生长锥表面的g蛋白耦联受体，通过gi将信号传递给plc ，进而激活pkc和ip3信号通路。 - Spla 2 can significantly inhibits egf - induced egf receptorautophosphorylation , which also resulted in the inhibitionon egf - induced phospholipase d activation and tyrosine phosphorylation of phospholipase c - g 1 . under the same condition , spla 2 can induce intracellular ceramidegeneration . moreover , exogenous ceramide analogs can also significantly inhibit such biologicalevent induced by egf , suggesting that ceramide may play an important role in spla 2 - induced cell death and the signaling events
在相同的条件下，分泌型磷脂酶a亦能诱导细胞内神经酰胺生2成的增加；外源性的神经酰胺类似物也能有效的抑制表皮生长因子诱导的这些生物事件，提示神经酰胺在分泌型磷脂酶a所介导的细胞死亡和信号传导事件2中起着重要的作用。 - The newly identified gene , nyd - sp27 has structural similarity to an isoform of phospholipase c . nyd - sp27 was expressed endogenously in human pancreatic - duct cells and upregulated in cystic fibrosis . researchers has proved that suppression of the gene resulted in augmentation of phospholipase - c - coupled calcium - ion release and protein kinase c activity , improvement in the amount of mutated cftr reaching the plasma membrane , and thus restoration of pancreatic anion secretion
Nyd - sp27内源性表达在人体的胰腺导管上皮细胞，并在囊性纤维化时表达增高，显示该基因可能与病变有关。研究人员发现通过抑制该基因在人体囊性纤维化胰腺导管细胞中的表达，可以纠正缺陷的胰腺阴离子分泌。 - Pretreatment with the phospholipase c inhibitor u73122 ( 5 umol / l ) significantly inhibited the il - 2 - induced depression of contraction . conclusion : it is concluded that the effect of il - 2 on contraction of ventricular myocytes is mediated via the cardiac k opioid receptor , and the post - receptor signal transduction pathway includes a ptx sensitive g protein and phospholipase c . 2 effect of interieukin - 2 on intracellular calcium tran
5 200u ffil ）浓度依赖性地降低单个心室肌细胞电刺激诱导的钙瞬变幅度，使舒张末钙水平升高； （ 2 ） il 2 （ 200u ml ）使咖啡因诱导的肌浆网内贮钙的释放降低： （ 3 ） 50偷i热失活！